Breast Cryoablation

Holmes, D.; Iyengar, G. Breast Cancer Cryoablation in the Multidisciplinary Setting: Practical Guidelines for Patients and Physicians. Life 2023, 13, 1756.

Janice N Thai, Alexander B Sevrukov, Robert C Ward, Debra L Monticciolo, Cryoablation Therapy for Early-Stage Breast Cancer: Evidence and Rationale, Journal of Breast Imaging, Volume 5, Issue 6, November-December 2023, Pages 646–657,

Holmes, D.R. Reducing the Risk of Needle Tract Seeding or Tumor Cell Dissemination during Needle Biopsy Procedures. Cancers 2024, 16, 317.

Michael J Plaza, Aswin V Kumar, Marcos A Sanchez-Gonzalez, Safety and Efficacy of Ultrasound-Guided Cryoablation for Benign Breast Fibroepithelial Lesions, Journal of Breast Imaging, Volume 1, Issue 4, December 2019, Pages 324–328,

Simmons RM, Ballman KV, Cox C, Carp N, Sabol J, Hwang RF, Attai D, Sabel M, Nathanson D, Kenler A, Gold L, Kaufman C, Han L, Bleznak A, Stanley Smith J, Holmes D, Fornage B, Le-Petross C, Hoda S, McCall L, Hunt KK; ACOSOG investigators. A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072. Ann Surg Oncol. 2016x Aug;23(8):2438-45. doi: 10.1245/s10434-016-5275-3. Epub 2016 May 24. PMID: 27221361; PMCID: PMC5433250.

Fine RE, Gilmore RC, Dietz JR, Boolbol SK, Berry MP, Han LK, Kenler AS, Sabel M, Tomkovich KR, VanderWalde NA, Chen M, Columbus KS, Curcio LD, Feldman SM, Gold L, Hernandez L, Manahan ER, Seedman SA, Vaidya RP, Sevrukov AB, Aoun HD, Hicks RD, Simmons RM. Cryoablation Without Excision for Low-Risk Early-Stage Breast Cancer: 3-Year Interim Analysis of Ipsilateral Breast Tumor Recurrence in the ICE3 Trial. Ann Surg Oncol. 2021 Oct;28(10):5525-5534. doi: 10.1245/s10434-021-10501-4. Epub 2021 Aug 15. PMID: 34392462.

Habrawi Z, Melkus MW, Khan S, Henderson J, Brandi L, Chu V, Layeequr Rahman R. Cryoablation: A promising non-operative therapy for low-risk breast cancer. Am J Surg. 2021 Jan;221(1):127-133. doi: 10.1016/j.amjsurg.2020.07.028. Epub 2020 Aug 1. PMID: 32788081.

Khan SY, Snitman A, Habrawi Z, Crawford S, Melkus MW, Layeequr Rahman R. The Role of Cryoablation in Breast Cancer Beyond the Oncologic Control: COST and Breast-Q Patient-Reported Outcomes. Ann Surg Oncol. 2023 Feb;30(2):1029-1037. doi: 10.1245/s10434-022-12570-5. Epub 2022 Sep 28. PMID: 36171531.

Pusceddu C, Paliogiannis P, Nigri G, Fancellu A. Cryoablation in the management of breast cancer: evidence to date. Breast Cancer: Targets Therapy 2019;11:283–292.

Cryoablation and immunotherapy
McArthur HL, Diab A, Page DB, Yuan J, Solomon SB, Sacchini V, Comstock C, Durack JC, Maybody M, Sung J, Ginsberg A, Wong P, Barlas A, Dong Z, Zhao C, Blum B, Patil S, Neville D, Comen EA, Morris EA, Kotin A, Brogi E, Wen YH, Morrow M, Lacouture ME, Sharma P, Allison JP, Hudis CA, Wolchok JD, Norton L. A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling. Clin Cancer Res. 2016 Dec 1;22(23):5729-5737. doi: 10.1158/1078-0432.CCR-16-0190. Epub 2016 Aug 26. PMID: 27566765; PMCID: PMC5161031.

Regen-Tuero H, Ward RC, Sikov WM, Littrup PJ. Cryoablation and immunotherapy for breast cancer: overview and rationale for combined therapy. Radiology: Imaging Cancer 2021;3(2):e200134.